Name: Lisbeth Marner (e-mail)
Title: MD, DMSc, PhD
• MD at Rigshospitalet, Copenhagen University Hospital, Dep. of Clinical Physiology, Nuclear Medicine and PET
Lisbeth Marner is specializing in clinical physiology and nuclear medicine and has her primary interest in neuroimaging and neuroresearch including kinetic modeling. Pregraduately, her research was focused on stereology with estimation of length of myelinated fibers in the brain white matter in healthy aging and in Alzheimer's disease. Postgraduately, the main focus has been on neuroPET with methodological studies in kinetic modeling as well as studies of Alzheimer's disease.
Lisbeth Marner is trained in reading clinical brain scans and has introduced brain FDG-PET imaging for neurodegenerative diseases at Herlev Hospital. Further, she is teaching at phd courses at Copenhagen University in kinetic modeling as well as imaging in Alzheimers disease.
1) Haahr ME, Fisher P, Holst K, Madsen K, Jensen CG, Marner L, Lehel S, Baaré W, Knudsen GM, Hasselbalch S. The 5-HT4 receptor levels in hippocampus correlates inversely with memory test performance in humans. Hum. Brain Mapp. 34(11):3066-74 (2013)
2) Haahr ME, Rasmussen PM, Madsen K, Marner L, Ratner C, Gillings N, Baaré WF, Knudsen GM. Obesity is associated with high serotonin 4 receptor availability in the brain reward circuitry. Neuroimage. 61(4)884-8 (2012).
3) Madsen K, Marner L, Haahr M, Gillings N, Knudsen GM. Mass dose effects and in vivo affinity in brain PET receptor studies – a study of cerebral 5-HT4 receptor binding with [11C]SB207145. Nucl Med Biol. 38(8):1085-91 (2011).
4) Madsen K, Neumann WJ, Holst K, Marner L, Lehel S, Knudsen GM, Hasselbalch SG. Cerebral serotonin 4 receptors and amyloid-b in Alzheimer’s disease. J Alz Dis. 26(3):457-66 (2011).
5) Madsen K, Haahr MT, Marner L, Keller SH, Baaré WF, Svarer C, Hasselbalch SG, Knudsen GM. Age and sex effects on 5-HT(4) receptors in the human brain: a [(11)C]SB207145 PET study. J Cereb Blood Flow Metab. 31(6):1575-81 (2011).
6) Marner L, Knudsen GM, Madsen K, Holm S, Baaré W, Hasselbalch SG. The reduction of baseline serotonin 2A receptors in mild cognitive impairment is stable at two-year follow-up. J Alzheimers Dis. 23(3):453-9 (2011).
7) Marner L, Frokjaer VG, Kalbitzer J, Lehel S, Madsen K, Baaré WF, Knudsen GM, Hasselbalch SG. Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer’s disease: a combined [(11)C]DASB and [(18)F]altanserin- PET study. Neurobiol Aging 33(3):479-87 (2012).
8) Marner L, Gillings N, Madsen K, Erritzoe D, Baaré WFC, Svarer C, Hasselbalch SG, Knudsen GM. Brain Imaging of Serotonin 4 Receptors in Humans with [11C]SB207145-PET. Neuroimage 50(3):855-61 (2010).
9) Kalbitzer J, Erritzoe D, Holst KK, Nielsen FÅ, Marner L, Lehel S, Arentzen T, Jernigan TL, Knudsen GM. Seasonal changes in brain serotonin transporter binding in short 5-HTTLPR-allele carriers but not in long-allele homozygotes. Biological Psychiatry 67(11):1033-9 (2010).
10) Marner L, Gillings N, Comley RA, Baaré WFC, Rabiner EA, Wilson AA, Houlse S, Hasselbalch SG, Svarer C, Gunn RN, Laruelle M, Knudsen GM. Kinetic modeling of [11C]SB207145 binding to 5-HT4 receptors in the human brain in vivo. Journal of Nuclear Medicine. 50(6):900-908 (2009).
11) Erritzoe D, Frokjaer V, Haugbol S, Marner L, Svarer C, Holst K, Baaré W, Rasmussen P, Madsen J, Paulson O. Brain serotonin 2A binding: Relations to body mass index, tobacco and alcohol use. Neuroimage. 46(1):23-30 (2009).
12) Marner L, Knudsen GM, Haugbøl S, Holm S, Baaré W, Hasselbalch SG. Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: An [18F]-altanserin PET study. European Journal of Nuclear Medicine and Molecular Imaging. 36(2):287-93 (2009).
13) Kornum BR, Lind NM, Gillings N, Marner L, Andersen F, Knudsen GM. Evaluation of the novel 5-HT4 Receptor PET ligand [11C]SB207145 in the Göttingen minipig. Journal of Cerebral Blood Flow and Metabolism. 29(1):186-96 (2009).
14) Jørgensen AM, Marner L, Pakkenberg B.: No Change in total length of white matter fibers in Alzheimer’s disease. Neuroscience 157(4):878-83 (2008).
15) Marner L, Søborg C, Pakkenberg B: Increased Volume of the Pigmented Neurons in the Locus Coeruleus of Schizophrenics – a stereological study. Journal of Psychiatric Research 39(4):337-345 (2005).
16) Pedersen KM, Marner L, Pakkenberg H, Pakkenberg, B. No Global Loss of Neocortical Neurons in Parkinson’s Disease – a quantitative stereological study. Movement Disorders 20(2):164-71 (2005).
17) Marner L, Nyengaard JR, Tang Y, Pakkenberg B: Marked Loss of Myelinated Nerve Fibers in the Human Brain with Age. The Journal of Comparative Neurology 462:144-152 (2003).
18) Marner L, Pakkenberg B: Total Length of Nerve Fibers in Prefrontal and Global White Matter of Chronic Schizophrenia. Journal of Psychiatric Research 37:539-547 (2003).
19) Pakkenberg B, Pelvig D, Marner L, Bundgaard MJ, Gundersen HJG, Nyengaard JR, Regeur L: Aging and the Human Neocortex. Experimental Gerontology 38(1-2):95-99 (2003).
The Curriculum Vitae can be downloaded here as a *PDF file: Lisbeth_Marner_CV.pdf